LSD for anxiety and psychedelic clinical trials with MindMed CMO, Dr. Daniel Karlin

In today’s episode of the Psychedelic Therapy Frontiers podcast Dr. Steve Thayer and Dr. Reid Robison are joined by Dr. Dan Karlin. Dan is Board Certified in Psychiatry, Addiction Medicine, and Clinical Informatics. He currently serves as the Chief Medical Officer of MindMed, a drug development company striving to deliver on the therapeutic potential of psychedelics to address unmet patient needs in psychiatry, addiction, pain, and neurology. Numinus is a trial site for MindMed’s MM-120 or LSD dose-finding study for the treatment of anxiety symptoms, so they discuss that study and what LSD treatment might look like in a post-approval clinical context. They discuss the challenges of mental health care accessibility and affordability, explore the philosophy behind the psychiatric diagnostic system, talk about the societal burden of anxiety, compare and contrast anxiety vs depression, and much more.

(2:35) Dr. Dan Karlin introduces himself and psychedelic studies
(13:34) The path to psychedelic approval
(16:37) Why anxiety?
(21:42) Why LSD?
(24:51) MM-120 and accessibility
(33:21) The burden of anxiety in society
(50:44) MindMed updates

Anxiety: Why we worry and what to do about it

In this episode of the Psychedelic Therapy Frontiers podcast, Dr. Steve Thayer and Dr. Reid Robison explore anxiety. They discuss the following topics:

(1:39) Introduction to the topic
(3:27) What is an anxiety disorder?
(5:45) Distress vs. Eustress
(7:10) Functional vs. Dysfunctional procrastination
(8:55) The role of avoidance in perpetuating dysfunctional anxiety
(12:56) Anxiety management skills
(18:00) Evolutionary perspectives on anxiety
(21:43) Cognitive distortions
(25:10) Somatic grounding techniques
(27:15) Exposure therapy for anxiety
(34:27) MDMA-assisted psychotherapy for PTSD
(36:35) The role of medicines in treating anxiety
(42:00) How is psychedelic medicine different than current psych meds?

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Disclaimer: The content of this podcast does not constitute medical advice or mental health treatment. Consult with a medical/mental health professional if you believe you are in need of mental health treatment.