LSD for anxiety and psychedelic clinical trials with MindMed CMO, Dr. Daniel Karlin

In today’s episode of the Psychedelic Therapy Frontiers podcast Dr. Steve Thayer and Dr. Reid Robison are joined by Dr. Dan Karlin. Dan is Board Certified in Psychiatry, Addiction Medicine, and Clinical Informatics. He currently serves as the Chief Medical Officer of MindMed, a drug development company striving to deliver on the therapeutic potential of psychedelics to address unmet patient needs in psychiatry, addiction, pain, and neurology. Numinus is a trial site for MindMed’s MM-120 or LSD dose-finding study for the treatment of anxiety symptoms, so they discuss that study and what LSD treatment might look like in a post-approval clinical context. They discuss the challenges of mental health care accessibility and affordability, explore the philosophy behind the psychiatric diagnostic system, talk about the societal burden of anxiety, compare and contrast anxiety vs depression, and much more.

(2:35) Dr. Dan Karlin introduces himself and psychedelic studies
(13:34) The path to psychedelic approval
(16:37) Why anxiety?
(21:42) Why LSD?
(24:51) MM-120 and accessibility
(33:21) The burden of anxiety in society
(50:44) MindMed updates

LSD, creativity, and insanity

In this episode of the Psychedelic Therapy Frontiers podcast, Dr. Steve Thayer and Dr. Reid Robison LSD research, phenomenology, and the future of LSD-assisted psychotherapy.

(1:03) Albert Hofmann's description of the first LSD experience on "bicycle day"
(4:13) Alex Grey artwork
(5:38) The stigma against LSD
(8:51) LSD as a treatment for alcoholism
(9:50) Big pharma
(12:15) Hofmann's letter to Steve Jobs
(13:44) LSD and creativity
(16:23) Default Mode Network
(17:51) LSD for anxiety disorders
(20:25) LSD is a "promiscuous" molecule
(22:00) The connection between creative genus and mental chaos
(24:37) LSD dosage pharmacology
(26:40) Ram Dass and Maharajji
(29:56) The importance of testing substances with kits like Dance Safe
(32:00) MK Ultra and the CIA
(32:41) Our LSD clinical trial
(34:12) Set and setting
(36:53) Fear of losing your mind on LSD
(39:49) Risks of LSD use

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Disclaimer: The content of this podcast does not constitute medical advice or mental health treatment. Consult with a medical/mental health professional if you believe you are in need of mental health treatment.