Psychedelic neurology, functional seizures, faith healing, and neuroplasticity with Dr. Evan Lewis

On this episode of Psychedelic Therapy Frontiers, Dr. Steve Thayer and Dr. Reid Robison are joined by Dr. Evan Lewis. Evan is a Neurologist and Clinical Neurophysiologist with expertise in pediatric neurology and epilepsy. At Numinus he’s the VP of Psychedelic Neurology and the medical director of our Toronto clinic. Evan has extensive clinical and research experience using medical cannabis and psychedelics to treat neurological disorders in adults and children. Link to Evan’s full bio HERE.

We have a wide-ranging conversation today.. We talk about the potential for psychedelics to treat neurological conditions like Alzheimer's, TBI, migraines, and functional seizures. We discuss what neuroplasticity actually means relative to what we think psychedelics do in the brain. We explore possible neurological explanations for faith healing and conversion disorders…and much more.

(2:43) Dr. Evan Lewis introduces himself
(7:48) Psychedelics and neurological conditions
(19:30) Functional blindness
(25:45) Faith healings
(41:44) Neuroplasticity
(53:02) Psychedelic pediatric neurology
(58:11) We are what we repeatedly do

The neuroscience of psychedelics and mental health

In this episode of the Psychedelic Therapy Frontiers podcast, Dr. Steve Thayer and Dr. Reid Robison discuss the neuroscience of psychedelics and mental health. Introduce basic neurochemistry, discuss the major neurotransmitters implicated in mental health, explore how psychotropic medicines affect neural circuits, and talk about how psychedelics affect neural circuitry.

(0:54) Positive review for the podcast
(2:07) The story of Phineas Gage
(7:15) Are we just meat machines? Biological reductionism
(12:13) Reid and Steve discuss their professional and personal journeys with psychedelics
(18:11) How to Change Your Mind, by Michael Pollan
(19:07) The ineffability of the psychedelic experience
(21:51) Default Mode Network
(28:54) What do psychiatric medications actually do?
(31:26) Non-medicine neurological interventions
(32:45) The Huberman Lab Podcast
(33:25) The electrical properties of physiology and mental health
(37:00) Serotonin and SSRIs
(38:56) Dopamine
(41:52) "feel good" and "negative" neurotransmitters
(46:20) The Art of Impossible, by Steven Kolter
(46:50) Oxytocin
(53:20) What are SSRIs doing?
(58:40) The Body Keeps The Score, by Bessel van der Kolk
(01:00:10) SSRI vs psilocybin
(01:05:46) LSD and DMT
(01:07:50) MDMA and neurotoxicity
(01:14:11) Roll Safe Kit
(01:17:14) Ketamine
(01:21:25) Critical learning periods opened by psychedelic medicines

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Disclaimer: The content of this podcast does not constitute medical advice or mental health treatment. Consult with a medical/mental health professional if you believe you are in need of mental health treatment.