The neuroscience of psychedelics and mental health



In this episode of the Psychedelic Therapy Frontiers podcast, Dr. Steve Thayer and Dr. Reid Robison discuss the neuroscience of psychedelics and mental health. Introduce basic neurochemistry, discuss the major neurotransmitters implicated in mental health, explore how psychotropic medicines affect neural circuits, and talk about how psychedelics affect neural circuitry.

(0:54) Positive review for the podcast
(2:07) The story of Phineas Gage
(7:15) Are we just meat machines? Biological reductionism
(12:13) Reid and Steve discuss their professional and personal journeys with psychedelics
(18:11) How to Change Your Mind, by Michael Pollan
(19:07) The ineffability of the psychedelic experience
(21:51) Default Mode Network
(28:54) What do psychiatric medications actually do?
(31:26) Non-medicine neurological interventions
(32:45) The Huberman Lab Podcast
(33:25) The electrical properties of physiology and mental health
(37:00) Serotonin and SSRIs
(38:56) Dopamine
(41:52) "feel good" and "negative" neurotransmitters
(46:20) The Art of Impossible, by Steven Kolter
(46:50) Oxytocin
(53:20) What are SSRIs doing?
(58:40) The Body Keeps The Score, by Bessel van der Kolk
(01:00:10) SSRI vs psilocybin
(01:05:46) LSD and DMT
(01:07:50) MDMA and neurotoxicity
(01:14:11) Roll Safe Kit
(01:17:14) Ketamine
(01:21:25) Critical learning periods opened by psychedelic medicines

Email us questions and feedback at
Learn more about our podcast at
Learn more about Novamind at
Follow us on Instagram:

Disclaimer: The content of this podcast does not constitute medical advice or mental health treatment. Consult with a medical/mental health professional if you believe you are in need of mental health treatment.

Would you like to be a guest
on our podcast?

Enter your info and we'll reach out to you asap.


Would you like to be a guest on our podcast?

By signing up you consent to the Privacy Policy & Terms of Use.
Call us toll-free 1-833-NUMINUS (686-4687)
crosschevron-down linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram