Intranasal ketamine used for treatment-resistant depression (those not seeing improvement with existing medication or therapy).

What is SPRAVATO® treatment?

SPRAVATO® (esketamine) and ketamine are chemically related, and both can produce treatment results that are both rapid and effective. The main difference is that esketamine is a version of ketamine that can be administered intranasally (through the nose), while most other ketamine treatments are  administered through injections. 

SPRAVATO® is combined with an oral antidepressant. Unlike conventional antidepressants, you do not need to use SPRAVATO® every day but can take it anywhere from twice weekly to monthly.

To learn more about this treatment, book a free informational call with one of our health navigators.

Approved For

  • Adults with treatment-resistant depression (those who have not had an adequate response to two or more antidepressants)
  • Adults with Major Depressive Disorder experiencing suicidal thoughts or actions.

How Does It Work?

SPRAVATO® treats depression in a different way than most conventional antidepressants. Ketamine targets the N-methyl-D-aspartate (NMDA) receptor, which results in increased activity of glutamate in the brain. Researchers believe this causes creation of new connections between neurons which in turn is believed to allow for new creation of positive thought and behaviour patterns in patients treated with ketamine. This is commonly referred to as neuroplasticity.


The Process

Here is what you can expect from your SPRAVATO® treatment.

Step 1: Evaluation

We’ll start with a thorough evaluation of your medical and mental health history, and an overview of your treatment goals.

Step 2: Creation of Plan

Your practitioner will determine your treatment plan - it may involve a mix of SPRAVATO®, oral antidepressants, and therapy.

Step 3: Treatment

Our SPRAVATO® treatment is a structured program that can involve multiple sessions. In these sessions, you will be given SPRAVATO®, under medical supervision, but generally without a therapist to guide you through the ketamine experience. SPRAVATO® is administered in our comfortable, peaceful, and monitored ketamine administration rooms in our clinics. 

Ketamine, in higher doses, can cause a “psychedelic” experience (changes in perception, out of body experience, dissociation). Some patients may prefer the support of a therapist. For more information on therapist supported ketamine treatments, please visit our Ketamine-Assisted Therapy and Ketamine Treatment pages.

Our Locations

SPRAVATO® is offered at our safe and comfortable clinics, designed with you in mind.

Montreal 393 Laurier West
393 Av. Laurier O, Montréal, QC H2V 2K3
Numinus Montreal 397 Laurier West
397 Laurier Ave W, Montreal QC H2V 2K3
Numinus Montreal Sherbrooke
5165 Sherbrooke St W, Suite 405, Montreal, QC H4A 1T6
Numinus Toronto Eglinton Avenue
491 Eglington Ave. W, Suite 100, Toronto, ON M5N 1A7

Schedule an informational call with a health navigator to get started.

Book Now


Spravato® is approved for treatment resistant depression.  Common side effects of ketamine include dizziness, nausea and vomiting. Ketamine raises heart rate and blood pressure, which can increase the risk of stroke or heart attack. People under the influence of ketamine may have difficulty standing up and be confused about their surroundings. Ketamine can cause vivid dreams or hallucinations, which may be intense and terrifying, and a feeling like the mind is separated from the body. Ketamine has been reported to cause apnea and respiratory depression as well as laryngospasm. Like all anesthetics, ketamine prevents users from feeling pain and, if injury occurs, a person may not know it. Frequent use of ketamine may cause bladder problems. Ketamine can cause psychosis and seizures. This also has a risk for abuse and physical and psychological dependence. The side effects above are not the only effects you will experience. In addition, there can be various other side effects. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Refer to the medication's official prescribing information. Always consult a physician or qualified health professional on any matters regarding your mental health or on any opinions expressed within this article.

Learn More About Ketamine

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